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Atrial fibrillation in chronic heart failure patients with reduced ejection fraction: The CHECK-HF registry

Authors :
Hans-Peter Brunner-La Rocca
Martin E.W. Hemels
Philip C. Rademaker
Paul H M Westendorp
Check-Hf Investigators
Frank J J Smeele
Gerard C.M. Linssen
Arno W. Hoes
Jasper J. Brugts
Jesse F. Veenis
Noëmi T A E Wouters
Michiel Rienstra
Cardiology
Cardiovascular Centre (CVC)
Cardiologie
MUMC+: MA Med Staf Spec Cardiologie (9)
RS: Carim - H02 Cardiomyopathy
Source :
International Journal of Cardiology, 308, 60-66. Elsevier Ireland Ltd, International Journal of Cardiology, 308, 60-66. ELSEVIER IRELAND LTD
Publication Year :
2020

Abstract

Atrial fibrillation (AF) is common in chronic heart failure (HF) patients and influences the choice and effects of drug and device therapy. In this large real-world HF registry, we studied whether the presence of AF affects the prescription of guideline-recommended HF therapy.We analyzed 8253 patients with chronic HF with reduced ejection fraction (HFrEF) from 34 Dutch outpatient clinics included in the period between 2013 and 2016 treated according to the 2012 ESC guidelines.2109 (25.6%) of these patients were in AF (mean age 76.8 ± 9.2 years, 65.0% were men) and 6.144 (74.4%) had no AF (mean age 70.7 ± 12.2 years, 63.6% were men). Patients with AF more often received beta-blockers (81.7% vs. 79.7%, p = 0.04), MRAs (57.1% vs. 51.7%, p < 0.01), diuretics (89.7% vs. 80.6%, p < 0.01) and digoxin (40.1% vs. 9.3%, p < 0.01) compared to patients without AF, whereas they less often receive renin-angiotensin-system (RAS)-inhibitors (76.1% vs. 83.1%, p < 0.01). The number of patients who received beta-blockers, RAS-inhibitor and MRA at ≥50% of the recommended target dose was comparable between those with and without AF (16.6% vs. 15.2%, p = 0.07).In this large cohort of chronic HFrEF patients, the prevalence of AF was high and we observed significant differences in prescription of both guideline-recommended HF between patients with and without AF.Copyright © 2020 Elsevier B.V. All rights reserved.

Details

Language :
English
ISSN :
01675273
Database :
OpenAIRE
Journal :
International Journal of Cardiology, 308, 60-66. Elsevier Ireland Ltd, International Journal of Cardiology, 308, 60-66. ELSEVIER IRELAND LTD
Accession number :
edsair.doi.dedup.....5069b4d444043a4cbad9dd7a8421f915