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Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice
- Source :
- J Neurotrauma
- Publication Year :
- 2019
- Publisher :
- Mary Ann Liebert Inc, 2019.
-
Abstract
- Neuroimaging plays an important role in assessing axonal pathology after traumatic spinal cord injury. However, coexisting inflammation confounds imaging assessment of the severity of axonal injury. Herein, we applied diffusion basis spectrum imaging (DBSI) to quantitatively differentiate and quantify underlying pathologies in traumatic spinal cord injury at 3 days post-injury. Results reveal that DBSI was capable of detecting and differentiating axonal injury, demyelination, and inflammation-associated edema and cell infiltration in contusion-injured spinal cords. DBSI was able to detect and quantify axonal loss in the presence of white matter tract swelling. The DBSI-defined apparent axonal volume correlated with the corresponding histological markers. DBSI-derived pathological metrics could serve as neuroimaging biomarkers to differentiate and quantify coexisting white matter pathologies in spinal cord injury, providing potential surrogate outcome measures to assess spinal cord injury progression and response to therapies.
- Subjects :
- 030506 rehabilitation
Pathology
medicine.medical_specialty
Axonal loss
Cell Count
Inflammation
Thoracic Vertebrae
White matter
Mice
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Edema
medicine
Animals
Pathological
Spinal cord injury
Spinal Cord Injuries
business.industry
Original Articles
medicine.disease
Axons
Mice, Inbred C57BL
Diffusion Magnetic Resonance Imaging
medicine.anatomical_structure
Female
Neurology (clinical)
medicine.symptom
0305 other medical science
business
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 15579042 and 08977151
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Neurotrauma
- Accession number :
- edsair.doi.dedup.....507ea5d40d5e065c6ccf8049f7705223