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Hexachloronaphthalene as a hemostasis disturbing factor in female Wistar rats - A pilot study
- Source :
- Chemosphere. 228
- Publication Year :
- 2019
-
Abstract
- Although Persistent Organic Pollutants (POPs) are some of the most dangerous environmental toxicants, data on their impact on hemostasis are virtually limited. 1,2,3,5,6,7-hexachloronaphthalene (PCN67) seems to be one of the most toxic congeners of polychlorinated naphthalenes (PCNs), which have recently been listed as POPs. The toxic effects of PCNs are similar to other chlorinated aromatics, e.g. polychlorinated dibenzo-p-dioxins (PCDDs), so an impact on hemostasis could not be excluded. Therefore, this study examines, for the first time, if short-term (two and four weeks) exposure of a mixture of hexachloronaphthalene congeners with a PCN67 as a predominant component to female Wistar rats may have an impact on selected hemostasis parameters, such as overall potential and kinetic parameters of clot formation and fibrinolysis; hematology and basic coagulology parameters. It also examines the influence of PCN67 on the stability of erythrocyte membranes. Obtained results indicate that PCN67 may be an important disturbing factor regarding both coagulation and fibrinolysis processes, as well as platelet count. Exposure to PCN67 significantly affected clot formation and lysis processes and diminished fibrinogen concentration after both administration periods. After two weeks of administration, an increased activated partial thromboplastin time (APTT) was noted; after four weeks - decreased platelet count with concomitant increased in mean platelet volume. Moreover, PCN67 may exert adverse effects on the red blood cells membrane stability, which were manifested by a statistically significant increase of red blood cells lysis.
- Subjects :
- medicine.medical_specialty
Environmental Engineering
Polychlorinated Dibenzodioxins
Health, Toxicology and Mutagenesis
medicine.medical_treatment
0208 environmental biotechnology
Pilot Projects
02 engineering and technology
010501 environmental sciences
Naphthalenes
Fibrinogen
01 natural sciences
Hemolysis
Internal medicine
Fibrinolysis
medicine
Environmental Chemistry
Animals
Platelet
Mean platelet volume
Rats, Wistar
0105 earth and related environmental sciences
Hemostasis
Hematology
medicine.diagnostic_test
Chemistry
Platelet Count
Erythrocyte Membrane
Public Health, Environmental and Occupational Health
General Medicine
General Chemistry
Pollution
020801 environmental engineering
Rats
Endocrinology
Coagulation
Environmental Pollutants
Female
Partial Thromboplastin Time
medicine.drug
Partial thromboplastin time
Subjects
Details
- ISSN :
- 18791298
- Volume :
- 228
- Database :
- OpenAIRE
- Journal :
- Chemosphere
- Accession number :
- edsair.doi.dedup.....507eb8b7bf2b14063cdfb910b09d6b23