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Prevalence of Autoantibodies to Cyclic Citrullinated Peptide in Patients with Rheumatic Diseases other than Rheumatoid Arthritis: A French Multicenter Study
- Source :
- Clinical Reviews in Allergy & Immunology. 34:40-44
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Our objective was to evaluate the prevalence of autoantibodies to cyclic citrullinated peptides (anti-CCP aAbs) in a cohort of patients with a variety of inflammatory or non-inflammatory rheumatic diseases other than rheumatoid arthritis (RA). Six hundred and nine serum samples were tested for anti-CCP aAbs and for rheumatoid factor (RF) using enzyme-linked immunosorbent assays and immunonephelometry. The prevalence of anti-CCP aAbs and RF reached 10% and 25%, respectively, using the positive cutoff value suggested by the manufacturers. Using a higher cutoff value (50 U/ml) for both aAbs, the prevalence was lower with 6% and 16%, respectively. The specificity of both markers for RA thus reached 94% and 84%, respectively. Anti-CCP aAbs were found to be elevated in inflammatory and also in non-inflammatory rheumatic diseases in the same proportion. Clinical data obtained for 36 positive patients showed that 17% developed RA within 5 years. In conclusion, anti-CCP aAbs are clearly more specific than RF for RA. Follow-up of anti-CCP aAbs-positive patients with inflammatory or non-inflammatory rheumatic diseases other than RA could be important considering the predictive value of these aAbs for the development of RA.
- Subjects :
- Male
musculoskeletal diseases
Allergy
medicine.medical_specialty
Arthritis
Enzyme-Linked Immunosorbent Assay
Peptides, Cyclic
Sensitivity and Specificity
Gastroenterology
Autoimmune Diseases
Arthritis, Rheumatoid
Predictive Value of Tests
Rheumatoid Factor
Rheumatic Diseases
Internal medicine
Prevalence
medicine
Humans
Immunology and Allergy
Rheumatoid factor
skin and connective tissue diseases
Aged
Autoantibodies
business.industry
Autoantibody
General Medicine
Middle Aged
medicine.disease
Multicenter study
Predictive value of tests
Rheumatoid arthritis
Immunology
Cohort
Female
France
business
Subjects
Details
- ISSN :
- 15590267 and 10800549
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Clinical Reviews in Allergy & Immunology
- Accession number :
- edsair.doi.dedup.....5093694efe301d7f1a70f8848e3dbdef