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Humoral and cellular immunity to SARS-CoV-2 vaccination in renal transplant versus dialysis patients: A prospective, multicenter observational study using mRNA-1273 or BNT162b2 mRNA vaccine
- Source :
- The Lancet Regional Health. Europe
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background: Dialysis and kidney transplant patients are vulnerable populations for COVID-19 related disease and mortality. Methods: We conducted a prospective study exploring the eight week time course of specific cellular (interferon-I³ release assay and flow cytometry) or/and humoral immune responses (ELISA) to SARS-CoV-2 boost vaccination in more than 3100 participants including medical personnel, dialysis patients and kidney transplant recipients using mRNA vaccines BNT162b2 or mRNA-1273. Results: SARS-CoV-2-vaccination induced seroconversion efficacy in dialysis patients was similar to medical personnel (> 95%), but markedly impaired in kidney transplant recipients (42%). T-cellular immunity largely mimicked humoral results. Major risk factors of seroconversion failure were immunosuppressive drug number and type (belatacept, MMF-MPA, calcineurin-inhibitors) as well as vaccine type (BNT162b2 mRNA). Seroconversion rates induced by mRNA-1273 compared to BNT162b2 vaccine were 97% to 88% (p
- Subjects :
- dialysis patients
Cellular immunity
medicine.medical_specialty
medicine.medical_treatment
Belatacept
mRNA-1273
humoral and cellular immune response
Immune system
medical personnel
Immunity
Internal medicine
Internal Medicine
medicine
guidelines
Seroconversion
Dialysis
clinical decision-making
business.industry
Health Policy
COVID-19
tozinameran
Vaccination
SARS-CoV-2 vaccination
Immunosuppressive drug
Oncology
epidemiology
BNT162b2
kidney transplant recipients
business
Research Paper
medicine.drug
Subjects
Details
- ISSN :
- 26667762
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- The Lancet Regional Health - Europe
- Accession number :
- edsair.doi.dedup.....50ba990e00aec67fd0e6eb5458fb794d