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Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non-alcoholic fatty liver disease

Authors :
Ngai-Moh Law
Carmen Jia Wen Kam
Gaik-Hong Soon
John Chen Hsiang
Tiing Leong Ang
Ranu Taneja
Seok-Hwee Koo
Joan Khoo
Source :
Liver international : official journal of the International Association for the Study of the Liver. 39(5)
Publication Year :
2018

Abstract

BACKGROUND & AIMS We compared the effects of weight loss induced with the glucagon-like peptide-1 agonist liraglutide, with that of lifestyle modification, followed by weight maintenance after discontinuing intervention, in obese adults with non-alcoholic fatty liver disease (NAFLD). METHODS Thirty obese (mean age 40.7 ± 9.1 years, BMI 33.2 ± 3.6 kg/m2 , 90% male) adults with NAFLD defined as liver fat fraction (LFF) > 5% on magnetic resonance imaging without other causes of hepatic steatosis were randomized to a supervised programme of energy restriction plus moderate-intensity exercise to induce ≥ 5% weight loss (DE group, n = 15), or liraglutide 3 mg daily (LI group, n = 15) for 26 weeks, followed by 26 weeks with only advice to prevent weight regain. RESULTS Diet and exercise and LI groups had significant (P

Details

ISSN :
14783231
Volume :
39
Issue :
5
Database :
OpenAIRE
Journal :
Liver international : official journal of the International Association for the Study of the Liver
Accession number :
edsair.doi.dedup.....50c68dabb4d8e986c81231ad0736125f