Genome-Wide Association Study Identifies Genetic Associations with Perceived Age

Authors :: Victoria Roberts
Nicholas J. Timpson
Barry Main
Simon Haworth
Source :: Roberts, V, Main, B, Timpson, N J & Haworth, S 2020, ' Genome wide association study identifies genetic associations with perceived age ', Journal of Investigative Dermatology . https://doi.org/10.1016/j.jid.2020.03.970, The Journal of Investigative Dermatology
Publication Year :: 2020
Publisher :: Elsevier BV, 2020.
Abstract: Failure of dermal protection or repair mechanisms might lead to visibly aged skin. The study aimed to identify genetic associations with perceived age. A genome-wide association study was undertaken in 423,992 adult participants of UK Biobank, using questionnaire data on perceived age and genetic data imputed to the Haplotype Reference Consortium imputation panel. Seventy-four to our knowledge previously unreported and independent associated genetic loci were identified (P

Subjects :: Male
0301 basic medicine
Linkage disequilibrium
BMI, body mass index
Genome-wide association study
Smad2 Protein
Human physical appearance
Biochemistry
0302 clinical medicine
NIMA-Related Kinases
Medicine
Protein Interaction Maps
Adiposity
Skin
Age Factors
Middle Aged
Biobank
Physical Appearance, Body
030220 oncology & carcinogenesis
Genetics/Genetic Disease
GCT-VL, Complex Trait Genomics Virtual Lab
Original Article
Female
ICEP
Signal Transduction
Adult
FDR, false discovery rate
LD, linkage disequilibrium
Ultraviolet Rays
Dermatology
MAF, minor allele frequency
Polymorphism, Single Nucleotide
03 medical and health sciences
Humans
GWAS, genome-wide association study
Molecular Biology
Aged
SNV, single nucleotide variant
business.industry
Haplotype
Cell Biology
Skin Aging
Minor allele frequency
030104 developmental biology
Genetic Loci
business
Body mass index
Imputation (genetics)
Genome-Wide Association Study
Demography

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