Back to Search
Start Over
An antioxidant, N,N′-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test
- Source :
- Food and Chemical Toxicology. 56:290-296
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28 days at 0, 100, 300, or 1000 mg/kg bw/day or for a total of 42-46 days at 0, 8, 50, or 300 mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000 mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300 mg/kg bw/day. Another female delivered only three live pups at 300 mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300 mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8 mg/kg bw/day, respectively.
- Subjects :
- Male
Antioxidant
media_common.quotation_subject
medicine.medical_treatment
Developmental toxicity
Phenylenediamines
Pharmacology
Toxicology
Rats, Sprague-Dawley
chemistry.chemical_compound
Animal science
Pregnancy
Toxicity Tests
medicine
Animals
Adverse effect
media_common
No-Observed-Adverse-Effect Level
Dose-Response Relationship, Drug
business.industry
Body Weight
Parturition
p-Phenylenediamine
General Medicine
Hypothermia
medicine.disease
Rats
chemistry
Toxicity
Pregnancy, Animal
Female
medicine.symptom
Reproduction
business
Food Science
Subjects
Details
- ISSN :
- 02786915
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....511847d72b0675b04c47ca3e12a5a3c1
- Full Text :
- https://doi.org/10.1016/j.fct.2013.02.029