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Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication
- Source :
- Cytokine & Growth Factor Reviews. 37:1-16
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- By interfering with the type I interferon (IFN1) response, human immunodeficiency virus 1 (HIV-1) can circumvent host antiviral signalling and establish persistent viral reservoirs. HIV-1-mediated defects in the IFN pathway are numerous, and include the impairment of protein receptors involved in pathogen detection, downstream signalling cascades required for IFN1 upregulation, and expression or function of key IFN1-inducible, antiviral proteins. Despite this, the activation of IFN1-inducible, antiviral proteins has been shown to facilitate the killing of latently HIV-infected cells in vitro. Understanding how IFN1 signalling is blocked in physiologically-relevant models of HIV-1 infection, and whether these defects can be reversed, is therefore of great importance for the development of novel therapeutic strategies aimed at eradicating the HIV-1 reservoir.
- Subjects :
- 0301 basic medicine
Endocrinology, Diabetes and Metabolism
Immunology
HIV Infections
Biology
Suppressor of cytokine signalling
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Interferon
medicine
Humans
Immunology and Allergy
Cells, Cultured
Immune Evasion
Toll-like receptor
RIG-I
Virology
Immunity, Innate
Up-Regulation
030104 developmental biology
Receptors, Pattern Recognition
Stimulator of interferon genes
Host-Pathogen Interactions
Interferon Type I
HIV-1
Interferon type I
Signal Transduction
Interferon regulatory factors
SAMHD1
medicine.drug
Subjects
Details
- ISSN :
- 13596101
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Cytokine & Growth Factor Reviews
- Accession number :
- edsair.doi.dedup.....511dd3306593da41870e3769154519e5
- Full Text :
- https://doi.org/10.1016/j.cytogfr.2017.04.004