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Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication

Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication

Authors :
Nischal Ranganath
Jonathan B. Angel
Teslin S. Sandstrom
Source :
Cytokine & Growth Factor Reviews. 37:1-16
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

By interfering with the type I interferon (IFN1) response, human immunodeficiency virus 1 (HIV-1) can circumvent host antiviral signalling and establish persistent viral reservoirs. HIV-1-mediated defects in the IFN pathway are numerous, and include the impairment of protein receptors involved in pathogen detection, downstream signalling cascades required for IFN1 upregulation, and expression or function of key IFN1-inducible, antiviral proteins. Despite this, the activation of IFN1-inducible, antiviral proteins has been shown to facilitate the killing of latently HIV-infected cells in vitro. Understanding how IFN1 signalling is blocked in physiologically-relevant models of HIV-1 infection, and whether these defects can be reversed, is therefore of great importance for the development of novel therapeutic strategies aimed at eradicating the HIV-1 reservoir.

Details

ISSN :
13596101
Volume :
37
Database :
OpenAIRE
Journal :
Cytokine & Growth Factor Reviews
Accession number :
edsair.doi.dedup.....511dd3306593da41870e3769154519e5
Full Text :
https://doi.org/10.1016/j.cytogfr.2017.04.004