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Selenol-Based Nucleophilic Reaction for the Preparation of Reactive Oxygen Species-Responsive Amphiphilic Diblock Copolymers
- Source :
- Polymers, Volume 11, Issue 5, Polymers, Vol 11, Iss 5, p 827 (2019)
- Publication Year :
- 2019
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2019.
-
Abstract
- Selenide-containing amphiphilic copolymers have shown significant potential for application in drug release systems. Herein, we present a methodology for the design of a reactive oxygen species-responsive amphiphilic diblock selenide-labeled copolymer. This copolymer with controlled molecular weight and narrow molecular weight distribution was prepared by sequential organoselenium-mediated reversible addition fragmentation chain transfer (Se-RAFT) polymerization and selenol-based nucleophilic reaction. Nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization time-to-flight (MALDI-TOF) techniques were used to characterize its structure. Its corresponding nanomicelles successfully formed through self-assembly from the copolymer itself. Such nanomicelles could rapidly disassemble under oxidative conditions due to the fragmentation of the Se&ndash<br />C bond. Therefore, this type of nanomicelle based on selenide-labeled amphiphilic copolymers potentially provides a new platform for drug delivery.
- Subjects :
- Polymers and Plastics
Chemistry
Selenol
Chain transfer
General Chemistry
Combinatorial chemistry
Article
selenol
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Nucleophile
Polymerization
Drug delivery
Amphiphile
drug delivery
Copolymer
Molar mass distribution
amphiphilic polymer
RAFT
Subjects
Details
- Language :
- English
- ISSN :
- 20734360
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....513f35f02db027d007de0f83da203d9a
- Full Text :
- https://doi.org/10.3390/polym11050827