The action of adrenalin and glucagon on the metabolism of phospholipids in rat liver

The incorporation of phosphate into the phospholipids of rat-liver slices incubated in vitro is stimulated by adrenalin; the 3 main types of phospholipids, phosphatidylcholine, phosphatidylethanolamine and inositolphosphatides, are all influenced in the same way. This action is not obtained with glucagon. The incorporation of amines (choline and serine) is either slightly decreased or not affected by the 2 hormones. The incorporation of inositol is considerably stimulated by adrenalin but not by glucagon or by Ado-3',5'- P . These results show that not all of the metabolic actions of adrenalin on the liver are shared by glucagon nor, probably, mediated by Ado-3',5'- P .