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BADGE, a synthetic antagonist for PPARγ, prevents steroid-related osteonecrosis in a rabbit model
- Source :
- BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-8 (2018), BMC Musculoskeletal Disorders
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background It was indicated that inhibition of PPARγ probably represents a novel therapy for steroid-related osteonecrosis. In this study, we investigated the preventive effects of PPARγ inhibition on steroid-related osteonecrosis in a rabbit model. Methods Rabbits were randomly divided into three groups (normal group, model group and BADGE group). Osteonecrosis was induced in rabbits in the model group and the BADGE group. The BADGE group also received bisphenol a diglycidyl ether(BADGE), a PPARγ antagonist, for 6 weeks. Results Histopathological results indicated that rabbits treated with BADGE exhibited significantly reduced osteonecrotic changes, incidence of osteonecrosis and bone marrow adiposity. Furthermore, BADGE-treated rabbits exhibited reduced intraosseous pressure and increased femoral blood perfusion. Micro-computed tomography and bone histomorphometry indicated that the BADGE group exhibited significantly improved bone quality and mineral appositional rate compared with the model group. Furthermore, the BADGE group showed a significant increase in circulating levels of the bone formation marker osteocalcin and reduced levels of the bone resorption marker TRACP. Overall, BADGE-treated rabbits exhibited reduced marrow adiposity concomitant with improved bone formation. Conclusions In conclusion, these observations demonstrated that pharmacological inhibition of PPARγ might represent an effective therapy for steroid-related osteonecrosis in the near future.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Peroxisome proliferator-activated receptor
Methylprednisolone
Bone resorption
Random Allocation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Rheumatology
Osteogenesis
Internal medicine
medicine
Animals
Orthopedics and Sports Medicine
Benzhydryl Compounds
Bisphenol A diglycidyl ether
Ppar γ
chemistry.chemical_classification
Adipogenesis
biology
business.industry
Antagonist
Osteonecrosis
PPAR gamma
Disease Models, Animal
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Osteocalcin
biology.protein
Epoxy Compounds
Steroids
Rabbits
Bone marrow
lcsh:RC925-935
business
Perfusion
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14712474
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Musculoskeletal Disorders
- Accession number :
- edsair.doi.dedup.....5157535616dde7189321a77c9d6e41d6