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Risk of Thrombosis in Adult Philadelphia-Positive ALL Treated with an Asparaginase-Free ALL Regimen
- Source :
- Current Oncology, Volume 28, Issue 1, Pages 16-137, Current Oncology, Vol 28, Iss 16, Pp 128-137 (2021)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Background: venous thromboembolism (VTE) is a well-known complication in adults with acute lymphoblastic leukemia (ALL), especially in patients treated with asparaginase (ASNase)-including regiments. However, VTE risk in adult Philadelphia-positive ALL (Ph+ve ALL) patients treated with non-hyperCVAD chemotherapy is unclear. In this study, we examined VTE incidence in adult Ph+ve ALL patients treated with imatinib plus a pediatric-inspired asparaginase (ASNase)-free regimen modified from the Dana Farber Cancer Institute (DFCI) ALL protocol. Methods: a single centre retrospective review of Ph+ve ALL patients treated at Princess Margaret Cancer Center (PMCC) from 2008&ndash<br />2019 with imatinib plus modified DFCI protocol was conducted. Results: of the 123 patients included, 30 (24.3%) had at least 1 radiology confirmed VTE event from diagnosis to the end of maintenance therapy. 86.7% (26/30) of the VTE events occurred during active treatment. Of all VTE events, the majority (53.3%) were DVT and/or PE while another significant portion were catheter-related (40.0%). Major bleeding was observed in 1 patient on VTE treatment with low molecular weight heparin (LMWH). Conclusion: a high VTE incidence (24.3%) was observed in adults Ph+ve ALL patients treated with imatinib plus an ASNase-free modified DFCI pediatric ALL protocol, suggesting prophylactic anticoagulation should be considered for all adult Ph+ve ALL patients including those treated with ASNase-free regimens.
- Subjects :
- Adult
Asparaginase
medicine.medical_specialty
philadelphia-positive acute leukemia
medicine.drug_class
medicine.medical_treatment
venous thromboembolism
Low molecular weight heparin
acute lymphoblastic leukemia
030204 cardiovascular system & hematology
Gastroenterology
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Maintenance therapy
Internal medicine
medicine
Humans
cardiovascular diseases
treatment-related thrombosis
Child
RC254-282
Retrospective Studies
Chemotherapy
business.industry
Incidence (epidemiology)
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Anticoagulants
Thrombosis
cancer-related thrombosis
Heparin, Low-Molecular-Weight
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Regimen
chemistry
030220 oncology & carcinogenesis
business
Complication
Subjects
Details
- Language :
- English
- ISSN :
- 17187729 and 11980052
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Current Oncology
- Accession number :
- edsair.doi.dedup.....515a92a612754448c6089b19b76a7583