Back to Search
Start Over
Identifying common trajectories of joint space narrowing over two years in knee osteoarthritis
- Source :
- Arthritis Care & Research. 63:1722-1728
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Objective Little is known about the natural history of knee osteoarthritis (OA). We sought to identify common patterns of joint space narrowing (JSN) in well-characterized knee OA patients in the placebo arm of a 2-year international study. Methods We performed secondary data analyses of 622 adults ages 39–80 years in North America (n = 310) and Europe (n = 312) with symptomatic knee OA. Fluoroscopically positioned semiflexed anteroposterior radiographs were obtained at 0, 12, and 24 months. Group-based trajectory modeling was used to identify distinctive groups of individuals with similar trajectories of JSN, taking into account sex, age, and body mass index. Results Seven groups were identified. Four exhibited joint space width (JSW) stability over 2 years representing the most common trajectory (71%), which was unrelated to initial JSW. Atypical courses included slow, rapid, and moderate progressors; most had significant JSN at study entry. Slow progressors (20%) had a mean JSN of 0.2 mm over 2 years. Only 2% of the sample demonstrated rapid JSN (2.1 mm), while 7% had JSN of 0.7 mm. Rapid progressors tended to be men, while slow and moderate progressors were older and heavier. Conclusion Most (70%) people with OA demonstrated no significant JSN over 2 years; 20% showed slow progression, 7% had moderate, and 2% had rapid JSN. Progressors tended to have less JSW at study entry and were older and heavier; rapid progressors were more likely to be men. Understanding common patterns of the course of knee OA may offer new opportunities to target those at greatest risk of disability.
- Subjects :
- Adult
Male
musculoskeletal diseases
medicine.medical_specialty
Joint space narrowing
Time Factors
Knee Joint
Osteoarthritis
Severity of Illness Index
Disability Evaluation
Rheumatology
Slow progression
Severity of illness
Humans
Medicine
Aged
Aged, 80 and over
Bone Density Conservation Agents
business.industry
Disease progression
Etidronic Acid
Middle Aged
Osteoarthritis, Knee
musculoskeletal system
medicine.disease
Europe
Radiography
Multicenter study
Risedronic acid
North America
Disease Progression
Physical therapy
Female
business
Risedronic Acid
Body mass index
medicine.drug
Subjects
Details
- ISSN :
- 2151464X
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Arthritis Care & Research
- Accession number :
- edsair.doi.dedup.....516ef53c598ae015a9721124043c3a40
- Full Text :
- https://doi.org/10.1002/acr.20614