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Isolated CEP17 Copy Number Gain in Invasive Breast Cancer Results in a 'Reverse' Amplification Status
- Source :
- International journal of surgical pathology, Vol. 29, no. 1, p. 76-77 (2021)
- Publication Year :
- 2021
- Publisher :
- Sage Publications, 2021.
-
Abstract
- Dual-color silver-enhanced in situ hybridization (SISH) is a well-established method for determining the HER2 gene amplification status in invasive breast cancers with equivocal “2+” HER2 protein expression. Dual-color SISH applies 2 different probes on a single tissue slide: a probe for the HER2 gene and a centromere 17 (CEP17) probe. [...]
- Subjects :
- Copy number gain
DNA Copy Number Variations
Receptor, ErbB-2
Biopsy
Centromere
Breast Neoplasms
In situ hybridization
Pathology and Forensic Medicine
Breast cancer
Gene duplication
medicine
Carcinoma
Humans
Breast
skin and connective tissue diseases
In Situ Hybridization
medicine.diagnostic_test
business.industry
Carcinoma, Ductal, Breast
Gene Amplification
medicine.disease
Immunohistochemistry
Cancer research
Surgery
Female
Anatomy
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International journal of surgical pathology, Vol. 29, no. 1, p. 76-77 (2021)
- Accession number :
- edsair.doi.dedup.....5176c2dba7a061b705ed77666f0b2b6f