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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
- Source :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2019, 51 (4), pp.636-648. ⟨10.1038/s41588-019-0378-y⟩, NATURE GENETICS, Nature Genetics, 51(4), 636, Bentley, A R, Sung, Y J, Brown, M R, Winkler, T W, Kraja, A T, Ntalla, I, Schwander, K, Chasman, D I, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, T M, Ding, J, Dorajoo, R, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Milaneschi, Y, Yuan, J-M, Penninx, B W J H, COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Society Scientific group, Lifelines Cohort, Pereira, C, Rauramaa, R, Redline, S, Samani, N J, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, L E, Wang, J-S, Wang, Y X, Wareham, N, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zeggini, E, Zheng, W, Bouchard, C, Evans, M K, Gudnason, V, Kardia, S L R, Liu, Y, Psaty, B M, Ridker, P M, Van Dam, R M, Hayward, C, van Duijn, C M, Tai, E-S, Wong, T Y, Loos, R J F, Franceschini, N, Rotter, J I, Zhu, X, Bierut, L J, Gauderman, W J, Rice, K M, Munroe, P B, Morrison, A C, Rao, D C, Rotimi, C N & Cupples, L A 2019, ' Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y, Bentley, A R, Sung, Y J, Brown, M R, Winkler, T W, Kraja, A T, Ntalla, I, Schwander, K, Chasman, D I, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, T M, Ding, J, Dorajoo, R, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Hsu, F C, Christensen, K, Wang, J S, Understanding Society Scientific Group, Lifelines Cohort, COGENT-Kidney Consortium & EPIC-InterAct Consortium 2019, ' Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y, COGENT-Kidney Consortium & Morris, A P 2019, ' Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y, Nature Genetics, 51(4), 636-+. Nature Publishing Group, Nature Genetics, 2019, 51 (4), pp.636-648. ⟨10.1038/s41588-019-0378-y⟩, Nature Genetics, 51(4), 636-648. Nature Publishing Group, 2019, ' Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids ', Nature Genetics, vol. 51, no. 4, pp. 636-648 . https://doi.org/10.1038/s41588-019-0378-y, Nature genetics
- Publication Year :
- 2019
-
Abstract
- The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.<br />Editorial summary: A multi-ancestry genome-wide gene-smoking interaction study identifies 13 new loci associated with serum lipids.
- Subjects :
- Male
Linkage disequilibrium
Blood lipids
Genome-wide association study
VARIANTS
SUSCEPTIBILITY
Environment interaction
Genome
Linkage Disequilibrium
MESH: Genotype
0302 clinical medicine
MESH: Aged, 80 and over
Genotype
NICOTINE METABOLISM
11 Medical and Health Sciences
Genetics & Heredity
Aged, 80 and over
Genetics
MESH: Aged
0303 health sciences
ARCHITECTURE
[STAT.AP]Statistics [stat]/Applications [stat.AP]
Genotype imputation
MESH: Middle Aged
CHOLESTEROL
Smoking
MESH: Life Style
Lifelines Cohort
Middle Aged
Lipids
3. Good health
ENVIRONMENT INTERACTION
GENOTYPE IMPUTATION
RISK LOCI
METAANALYSIS
CIGARETTES
Cholesterol
MESH: Linkage Disequilibrium
MESH: Young Adult
Meta-analysis
Genome-Wide Association Study/methods
Smoking/blood
Medical genetics
Female
EPIC-InterAct Consortium
Life Sciences & Biomedicine
[STAT.ME]Statistics [stat]/Methodology [stat.ME]
Adult
Metaanalysi
Understanding Society Scientific Group
medicine.medical_specialty
MESH: Smoking
Adolescent
Genomics
COGENT-Kidney Consortium
Biology
Nicotine metabolism
Risk loci
Metaanalysis
Cigarettes
Article
Young Adult
03 medical and health sciences
genomics
medicine
Humans
Linkage Disequilibrium/genetics
Life Style
Aged
030304 developmental biology
MESH: Adolescent
Science & Technology
MESH: Humans
Lipids/blood
MESH: Adult
06 Biological Sciences
MESH: Lipids
MESH: Male
cardiovascular diseases
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
genome-wide association studies
MESH: Genome-Wide Association Study
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
MESH: Female
030217 neurology & neurosurgery
Developmental Biology
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 15461718 and 10614036
- Volume :
- 51
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nature Genetics
- Accession number :
- edsair.doi.dedup.....5177e19ad850477c3c810e7883a94b85
- Full Text :
- https://doi.org/10.1038/s41588-019-0378-y⟩