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Synthesis of 1-substituted phenazines as novel antichlamydial agents
- Source :
- Journal of Asian natural products research. 24(9)
- Publication Year :
- 2021
-
Abstract
- A novel series of 1-substituted phenazines 4a-4l were designed and synthesized via Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC50 values from 1 to 10 μM. Among them, compounds 4c and 4i exhibited the best antichlamydial activity with IC50 values from 2.06 to 2.74 μM without apparent cytotoxicity to host cells.
- Subjects :
- Pharmacology
Molecular Structure
Chemistry
Organic Chemistry
Pharmaceutical Science
General Medicine
Combinatorial chemistry
Analytical Chemistry
Structure-Activity Relationship
Complementary and alternative medicine
Drug Discovery
Ic50 values
Molecular Medicine
Phenazines
Cytotoxicity
Trifluoromethanesulfonate
Palladium
Subjects
Details
- ISSN :
- 14772213
- Volume :
- 24
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of Asian natural products research
- Accession number :
- edsair.doi.dedup.....51790b103bc458883d7bc08fda994679