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In vitro toxicity of trichothecenes on human erythroblastic progenitors
In vitro toxicity of trichothecenes on human erythroblastic progenitors
- Source :
- Humanexperimental toxicology. 16(11)
- Publication Year :
- 1998
-
Abstract
- Trichothecenes are mycotoxins produced by various species of fungi which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and potent trichothe cenes. Consumption of trichothecene contaminated foods by farm animals and humans leads to mycotoxicoses. Trichothecenes are known to induce haematologic dis orders such as neutropenia, thrombopenia, and aplastic anemia in human and animals. The aim of our investigations is to explore the effects of trichothecenes on the haematopoietic progenitors. The four trichothecenes previously demonstrated to be strongly cytotoxic for human CFU-GM have been tested on human BFU-E. For this purpose, a culture model of human erythroblastic progenitors (BFU-E) optimized for toxicological studies was used to determine the effects of T-2, HT-2, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) on red blood cell precursor proliferation and differentiation. Results showed that human BFU-E are as sensitive to trichothecenes as human CFU-GM, except for DON, in the range of concentrations tested. Differentiation of erythroblastic progenitors could be perturbed by these mycotoxins. Human erythroblastic progenitors are also a target of trichothecenes.
- Subjects :
- Porphyrins
Health, Toxicology and Mutagenesis
Trichothecene
Biology
Toxicology
medicine.disease_cause
030226 pharmacology & pharmacy
Diacetoxyscirpenol
03 medical and health sciences
chemistry.chemical_compound
Hemoglobins
0302 clinical medicine
hemic and lymphatic diseases
medicine
Humans
Progenitor cell
Mycotoxin
Erythroid Precursor Cells
Toxin
Cell Differentiation
General Medicine
In vitro
Haematopoiesis
T-2 Toxin
chemistry
030220 oncology & carcinogenesis
Toxicity
Immunology
Trichothecenes
Cell Division
Subjects
Details
- ISSN :
- 09603271
- Volume :
- 16
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Humanexperimental toxicology
- Accession number :
- edsair.doi.dedup.....51822946e13415235586b476ae739e3c