Back to Search
Start Over
Effects of passage through the digestive tract on incretin secretion: Before and after birth
- Source :
- Journal of Diabetes Investigation, Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 970-977 (2021)
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Aims/Introduction It was reported that fetuses secrete endogenous incretin; however, the stimulants of fetal incretin secretion are not fully understood. To investigate the association between the passage of amniotic fluid through the intestinal tract and fetal secretion of incretin, we analyzed umbilical cord incretin levels of infants with duodenum atresia. Materials and Methods Infants born from July 2017 to July 2019 (infants with duodenum atresia and normal term or preterm infants) were enrolled. We measured and compared the concentrations of glucagon‐like peptide‐1 (GLP‐1) and gastric inhibitory peptide/glucose‐dependent insulinotropic polypeptide (GIP) in the umbilical vein and preprandial blood samples after birth. Results A total of 98 infants (47 term, 46 preterm and 5 with duodenum atresia) were included. In patients with duodenum atresia, umbilical vein GLP‐1 and GIP levels were the same as those in normal infants. In postnatal samples, there were positive correlations between the amount of enteral feeding and preprandial serum concentrations of GLP‐1 (r = 0.47) or GIP (r = 0.49). Conclusions Our results show that enteral feeding is important for secretion of GLP‐1 and GIP in postnatal infants, whereas the passage of amniotic fluid is not important for fetal secretion of GLP‐1 and GIP. The effect of ingested material passing through the digestive tract on incretin secretion might change before and after birth. Other factors might stimulate secretion of GLP‐1 and GIP during the fetal period.<br />Enteral feeding is important for secretion of glucagon‐like peptide‐1 and gastric inhibitory peptide/glucose‐dependent insulinotropic polypeptide in postnatal infants, whereas the passage of amniotic fluid is not important for fetal secretion of glucagon‐like peptide‐1 and inhibitory peptide/glucose‐dependent insulinotropic polypeptide. The effect of ingested material passing through the digestive tract on incretin secretion might change before and after birth.
- Subjects :
- Male
0301 basic medicine
Amniotic fluid
Endocrinology, Diabetes and Metabolism
Enteral administration
Umbilical cord
Umbilical Cord
0302 clinical medicine
Glucagon-Like Peptide 1
Pregnancy
Medicine
digestive, oral, and skin physiology
General Medicine
Articles
Glucagon-like peptide-1
Glucagon‐like peptide‐1
medicine.anatomical_structure
Clinical Science and Care
Female
Original Article
Corrigendum
Infant, Premature
hormones, hormone substitutes, and hormone antagonists
medicine.medical_specialty
endocrine system
Intestinal Atresia
Incretin
030209 endocrinology & metabolism
Gastric Inhibitory Polypeptide
Incretins
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Enteral Nutrition
Fetus
Glucose‐dependent insulinotropic polypeptide
Internal medicine
Internal Medicine
Humans
Duodenal Diseases
Intestinal Secretions
business.industry
Infant, Newborn
RC648-665
medicine.disease
Gastrointestinal Tract
030104 developmental biology
Endocrinology
Atresia
Duodenum
business
Subjects
Details
- Language :
- English
- ISSN :
- 20401124 and 20401116
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Investigation
- Accession number :
- edsair.doi.dedup.....518771fb024eb99c90d8eb43cf715f87