Potential Refinement of Recurrence Score by pSTAT3 Status

Authors :: Albert Grinshpun
Yogev Cohen
Aviad Zick
Luna Kadouri
Tamar Hamburger
Benjamin Nisman
Tanir M. Allweis
Gabriela Oprea
Tamar Peretz
Beatrice Uziely
Amir Sonnenblick
Source :: Genes; Volume 13; Issue 3; Pages: 438
Publication Year :: 2022
Publisher :: Multidisciplinary Digital Publishing Institute, 2022.
Abstract: The likelihood of recurrence in breast cancer patients with hormone receptor-positive (HR-positive) tumors is influenced by clinical, histopathological, and molecular features. Recent studies suggested that activated STAT3 (pSTAT3) might serve as a biomarker of outcome in breast cancer patients. In the present work, we have analyzed the added value of pSTAT3 to OncotypeDx Recurrence Score (RS) in patient prognostication. We have found that patients with low RS (