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Neurophysiological modulation of the subthalamic nucleus by pallidal stimulation in Parkinson's disease
- Source :
- Journal of neurology, neurosurgery, and psychiatry. 72(3)
- Publication Year :
- 2002
-
Abstract
- Objectives: Current models of basal ganglia dysfunction in Parkinson9s disease suggest a pivotal role of subthalamic nucleus (STN) hyperactivity. There is a direct excitatory output to the globus pallidus internus (GPi), which in turn hyperinhibits the motor thalamus and leads to a lack of cortical facilitation. The model, however, does not address the reciprocal influence of GPi on STN activity. Methods: Measurement of immediate changes in STN single cell activity after GPi deep brain stimulation (DBS). Results: An opposite effect of GPi DBS in the dorsal versus ventral STN was found. There was an almost exclusive reduction of firing rate in the dorsal region of the STN, whereas the cells in the ventral region exhibited facilitation similar to the recordings from the substantia nigra pars reticulata. Conclusion: Although these findings require confirmation, they suggest that the current theories of GPi DBS action, which do not include a GPi-STN modulation, are most likely incomplete.
- Subjects :
- Male
Paper
Parkinson's disease
Deep brain stimulation
medicine.medical_treatment
Thalamus
Electric Stimulation Therapy
Globus Pallidus
Synaptic Transmission
Central nervous system disease
Degenerative disease
Subthalamic Nucleus
Neural Pathways
medicine
Humans
Dominance, Cerebral
Aged
Neurons
Brain Mapping
Neural Inhibition
Parkinson Disease
medicine.disease
Electric Stimulation
nervous system diseases
Electrodes, Implanted
Substantia Nigra
Psychiatry and Mental health
Subthalamic nucleus
surgical procedures, operative
nervous system
Facilitation
Excitatory postsynaptic potential
Surgery
Neurology (clinical)
Psychology
therapeutics
Neuroscience
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 72
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Accession number :
- edsair.doi.dedup.....51a19d30132d46b62b7fa7c4e610926b