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Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 10, p e0259085 (2021), PLoS ONE, Vol 16, Iss 10 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of PCSKs and their association with diseases; however, studies on the evolutionary history and diversification of these proteins are missing. In the present research, a bioinformatics study was conducted on the molecular evolution of several PCSKs family members and gene loss events across placental mammalian. In order to detect evolutionary constraints and positive selection, the CodeML program of the PAML package was used. The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in PCSK7, PCSK3, and MBTPS1 in Carnivores compared to the rest of phylogeny, and an accelerated evolution of PCSK1, PCSK7, and MBTPS1 in Muridae family of rodents was found. Additionally, our results indicated pcsk9 gene loss in 12 species comprising Carnivores and bats (Chiroptera). Future studies are required to evaluate the functional relevance and selective evolutionary advantages associated with these modifications in PCSK proteins during evolution.
- Subjects :
- Evolutionary Genetics
Computer and Information Sciences
Evolutionary Processes
Science
Carnivora
Biology
Serine
Evolution, Molecular
PCSK9 Gene
Camels
Molecular evolution
Phylogenetics
Bovines
Genetics
Animals
Evolutionary Systematics
Domestic Animals
Selection, Genetic
Gene
Phylogeny
Taxonomy
Data Management
Mammals
Evolutionary Biology
Multidisciplinary
Natural selection
Mammalian Genomics
Eutheria
Organisms
Biology and Life Sciences
Eukaryota
Phylogenetic Analysis
Genomics
Ruminants
Evolutionary biology
Animal Genomics
Vertebrates
Amniotes
Medicine
Evolutionary Rate
Rate of evolution
Cattle
Proprotein Convertases
Zoology
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....51af7386556c27a655da56214fbb94b6