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Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: Clinical analysis of 12 clustered adults and a proposed therapeutic algorithm
- Source :
- Journal of Microbiology, Immunology and Infection, Vol 53, Iss 5, Pp 766-777 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Purpose: Postoperative endophthalmitis caused by nontuberculous mycobacterium is a rare but devastating complication after intraocular surgery. However, optimal treatment strategies remain undetermined in view of its rarity. Methods: We investigated the cases of culture-proven postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis in southern Taiwan, focusing on clinical manifestations and microbiological study, and aimed to describe clinical staging and to propose a therapeutic modality for this disease. Results: Twelve cases, including two published cases, were treated in two medical centers in southern Taiwan between Aug. 2011 and Dec. 2016, and all ever received cataract surgery at one clinic. Their disease courses could be categorized into four distinct stages, i.e., the initial, quiescent, recurrent, and end stage, and some cases experienced 1–4 cycles of quiescent-recurrent stages. Although all eyes ended up with phthisis or were eviscerated, the affected eyes receiving pars plana vitrectomy (PPV) tended to become quiescent and survived longer than those without PPV (adjusted hazard ratio: 13.9, p
- Subjects :
- Male
0301 basic medicine
genetic structures
medicine.medical_treatment
lcsh:QR1-502
Vitrectomy
Eye
lcsh:Microbiology
Postoperative Complications
0302 clinical medicine
Endophthalmitis
Immunology and Allergy
030212 general & internal medicine
Stage (cooking)
Aged, 80 and over
Mycobacterium abscessus
Clinical pathology
Hazard ratio
Nontuberculous Mycobacteria
General Medicine
Middle Aged
Anti-Bacterial Agents
Infectious Diseases
medicine.anatomical_structure
Female
Algorithms
Adult
Microbiology (medical)
Pars plana
medicine.medical_specialty
Adolescent
030106 microbiology
Taiwan
Mycobacterium Infections, Nontuberculous
Microbial Sensitivity Tests
Young Adult
03 medical and health sciences
Clarithromycin
medicine
Humans
Amikacin
Aged
General Immunology and Microbiology
business.industry
Cataract surgery
medicine.disease
Surgery
Mycobacteroides abscessus subsp. abscessus
Complication
business
Subjects
Details
- ISSN :
- 16841182
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Journal of Microbiology, Immunology and Infection
- Accession number :
- edsair.doi.dedup.....51c97781cd9280d08af19175ed5e6124
- Full Text :
- https://doi.org/10.1016/j.jmii.2018.12.011