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Evidence based anti-osteoporosis effects of Periplaneta americana L on osteoblasts, osteoclasts, vascular endothelial cells and bone marrow derived mesenchymal stem cells
- Source :
- BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-12 (2017), BMC Complementary and Alternative Medicine
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Background Kangfuxin (KFX) is the ethanol extract of Periplaneta americana L, which has been widely used in the Traditional Chinese Medicine for the repair and regeneration of injured organ and tissues with long history. This study is to investigate the influence of KFX in the various cellular activities and evaluate the anti-osteoporosis potential of KFX. Methods The influence of the KFX in the cellular activities, including: 1) migration, osteocalcin secretion of osteoblasts; 2) apoptosis of osteoclasts; 3) migration and tube formation of human umbilical vein endothelial cell (HUVEC); and 4) proliferation, cell cycle regulation and migration of bone marrow mesenchymal stem cells (BMSCs), were investigated systematically. Results KFX was shown to significantly 1) Promote of the migration of osteoblasts, HUVEC, and BMSCs; 2) Increase the secretion of osteocalcin and mineralization of osteoblasts; 3) Accelerate the apoptosis of osteoclasts; 4) Stimulate the proliferation and regulate the cell cycle of BMSCs. Conclusion Taken together, these results provide the evidence for the osteogenesis, anti-osteoporosis and angiogenesis effects of KFX, with the mechanism of activating the bone formation through stimulating the osteoblasts and HUVECs, as well as inhibiting the bone absorption by inhibiting the osteoclasts activities. The KFX was definitely shown a promising bone turnover agent with great potential for anti-osteoporosis treatment.
- Subjects :
- 0301 basic medicine
Pathology
Angiogenesis
Osteoclasts
Apoptosis
Bone remodeling
Mice
0302 clinical medicine
Bone Marrow
Cell Movement
Osteogenesis
Medicine
Periplaneta
Anti-osteoporosis
HUVECs
Tube formation
biology
Bone Density Conservation Agents
Cell Cycle
General Medicine
lcsh:Other systems of medicine
Periplaneta americana L
Cell biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Osteocalcin
Human umbilical vein endothelial cell
BMSCs
Research Article
musculoskeletal diseases
medicine.medical_specialty
Neovascularization, Physiologic
Bone Marrow Cells
Bone resorption
03 medical and health sciences
Human Umbilical Vein Endothelial Cells
Animals
Humans
Bone Resorption
Cell Proliferation
Osteoblasts
business.industry
Plant Extracts
Mesenchymal stem cell
Endothelial Cells
Mesenchymal Stem Cells
lcsh:RZ201-999
030104 developmental biology
Complementary and alternative medicine
biology.protein
Osteoporosis
Bone marrow
Endothelium, Vascular
business
Phytotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 14726882
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....51d429dafd55938d83ee15181f95d09f