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The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 3016, p 3016 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30–40%, but may reach up to 70–80% in predisposed groups of women. UFs may cause various clinical issues which might constitute the major reason of the overall deterioration of the quality of life. The mechanisms leading to UFs formation and growth still remain poorly understood. The transformation of smooth muscle cells of the uterus into abnormal, immortal cells, capable of clonal division, is thought to be a starting point of all pathways leading to UF formation. Micro-ribonucleic acids (miRNAs) are non-coding single-stranded RNAs about 22 nucleotides in length, that regulate gene expression. One of recent advances in this field is the comprehension of the role of miRNAs in tumorigenesis. Alterations in the levels of miRNAs are related to the formation and growth of several tumors which show a distinct miRNA signature. The aim of this review is to summarize the current data about the role of miRNAs in the pathophysiology of UFs. We also discuss future directions in the miRNA research area with an emphasis on novel diagnostic opportunities or patient-tailored therapies. In our opinion data concerning the regulation of miRNA and its gene targets in the UFs are still insufficient in comparison with gynecological malignancies. The potential translational use of miRNA and derived technologies in the clinical care is at the early phase and needs far more evidence. However, it is one of the main areas of interest for the future as the use of miRNAs in the diagnostics and treatment of UFs is a new and exciting opportunity.
- Subjects :
- 0301 basic medicine
diagnosis
non-coding RNA
Review
Bioinformatics
medicine.disease_cause
Translational Research, Biomedical
lcsh:Chemistry
0302 clinical medicine
Smooth muscle
Medicine
lcsh:QH301-705.5
Spectroscopy
pathophysiology
030219 obstetrics & reproductive medicine
treatment
Leiomyoma
microRNA
biology
General Medicine
uterine fibroid
Non-coding RNA
Pathophysiology
Computer Science Applications
Multigene Family
Female
Disease Susceptibility
Early phase
Signal Transduction
Uterine fibroids
Catalysis
Inorganic Chemistry
03 medical and health sciences
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
miRNA
uterine leiomyoma
business.industry
Organic Chemistry
medicine.disease
Bench to bedside
MicroRNAs
030104 developmental biology
Gene Expression Regulation
lcsh:Biology (General)
lcsh:QD1-999
business
Carcinogenesis
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 3016
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....51d8ffe38c8b26ae67aad6d15b009920