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Short intrinsically disordered polypeptide–oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability
- Source :
- Soft Matter. 17:1184-1188
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.
- Subjects :
- Biocompatibility
010405 organic chemistry
Chemistry
Oligonucleotide
Oligonucleotides
Temperature
General Chemistry
Conjugated system
010402 general chemistry
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
Controllability
Biophysics
Drug encapsulation
Self-assembly
Peptides
Nanospheres
Conjugate
Subjects
Details
- ISSN :
- 17446848 and 1744683X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Soft Matter
- Accession number :
- edsair.doi.dedup.....51e1989cb64a1e6d4961cdc31697c284