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LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1
- Source :
- Cell Cycle
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- PSMG3-AS1 is a characterized oncogenic lncRNA in breast cancer, while its role in other cancers remains unclear. This study was to investigate the role and underlying mechansim of PSMG3-AS1 in non-small cell lung cancer (NSCLC). In this study, we found that PSMG3-AS1 could interact with miR-613. The expression of PSMG3-AS1 was upregulated in NSCLC, while the expression of miR-613 was downregulated in NSCLC. However, PSMG3-AS1 and miR-613 were not significantly correlated with each other. In NSCLC cells, PSMG3-AS1 and miR-613 overexpression failed to regulate the expression of each other. Interestingly, PSMG3-AS1 overexpression led to upregulated SphK1, a downstream target of miR-613. In addition, PSMG3-AS1 overexpression reduced the inhibitory effects of miR-613 on NSCLC cell proliferation. Therefore, PSMG3-AS1 may promote the proliferation of NSCLC cells by sponging miR-613 to upregulate SphK1.
- Subjects :
- 0301 basic medicine
Lung Neoplasms
Biology
03 medical and health sciences
0302 clinical medicine
Breast cancer
Downregulation and upregulation
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
medicine
Humans
Lung cancer
Molecular Biology
Cell Proliferation
Base Sequence
Nsclc cell
Cell Biology
medicine.disease
Up-Regulation
respiratory tract diseases
Gene Expression Regulation, Neoplastic
MicroRNAs
Phosphotransferases (Alcohol Group Acceptor)
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
RNA, Long Noncoding
Non small cell
Research Paper
Developmental Biology
Subjects
Details
- ISSN :
- 15514005 and 15384101
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Cell Cycle
- Accession number :
- edsair.doi.dedup.....51eca800833c252488f43ea2ec746af1