Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma

Authors :: Jose A. Hardillo
Jolique A van Ipenburg
Martine J. de Herdt
Rick de Jong
Senada Koljenović
Marc Lucas Ooft
Cathy B. Moelans
R. Baatenburg de Jong
Rob J. M. van de Loo
Stefan M. Willems
Remco de Bree
Pathology
Otorhinolaryngology and Head and Neck Surgery
Source :: Head & neck, 40(9), 1986. John Wiley and Sons Inc., Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 40(9), 1986-1998. John Wiley & Sons Inc.
Publication Year :: 2018
Publisher :: Wiley, 2018.
Abstract: Background: Nasopharyngeal carcinoma (NPC) treatment is mainly based on clinical staging. We hypothesize that better understanding of the molecular heterogeneity of NPC can aid in better treatment decisions. Therefore, the purpose of this study was to present our exploration of cancer gene copy-number alterations (CNAs) of Epstein-Barr virus (EBV)-positive and EBV-negative NPC. Methods: Multiplex ligation-dependent probe amplification was applied to detect CNAs of 36 cancer genes (n = 103). Correlation between CNAs, clinicopathological features, and survival were examined. Results: The CNAs occurred significantly more in EBV-negative NPC, with PIK3CA and MCCC1 (P

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