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Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma
- Source :
- Head & neck, 40(9), 1986. John Wiley and Sons Inc., Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 40(9), 1986-1998. John Wiley & Sons Inc.
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background: Nasopharyngeal carcinoma (NPC) treatment is mainly based on clinical staging. We hypothesize that better understanding of the molecular heterogeneity of NPC can aid in better treatment decisions. Therefore, the purpose of this study was to present our exploration of cancer gene copy-number alterations (CNAs) of Epstein-Barr virus (EBV)-positive and EBV-negative NPC. Methods: Multiplex ligation-dependent probe amplification was applied to detect CNAs of 36 cancer genes (n = 103). Correlation between CNAs, clinicopathological features, and survival were examined. Results: The CNAs occurred significantly more in EBV-negative NPC, with PIK3CA and MCCC1 (P
- Subjects :
- Adult
Male
0301 basic medicine
Epstein-Barr Virus Infections
nasopharyngealcarcinoma
DNA Copy Number Variations
PTK2
medicine.disease_cause
Virus
copy-number alterations
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
otorhinolaryngologic diseases
medicine
Humans
Epstein-Barr virus
Multiplex ligation-dependent probe amplification
gene
multiplex ligation-dependent probe amplification
Gene
Aged
Nasopharyngeal Carcinoma
business.industry
Nasopharyngeal Neoplasms
Epstein-Barr Virus Positive
Middle Aged
medicine.disease
Epstein–Barr virus
stomatognathic diseases
030104 developmental biology
Otorhinolaryngology
Nasopharyngeal carcinoma
Case-Control Studies
030220 oncology & carcinogenesis
Cancer research
Female
Carcinogenesis
business
Subjects
Details
- ISSN :
- 10433074
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....520fc20d0d37405c9d0b0a5021f12ebf