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Impact of High-Flow Nasal Cannula Oxygenation on the Prevention of Hypoxia During Endoscopic Retrograde Cholangiopancreatography in Elderly Patients: A Randomized Clinical Trial
- Source :
- Digestive Diseases and Sciences. 67:4154-4160
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Hypoxia is the most frequently occurring adverse effect during endoscopic retrograde cholangiopancreatography (ERCP) under sedation; thus, oxygen must be properly supplied to prevent a reduction of oxygen saturation. In this study, we intend to verify the preventive effect for hypoxia during ERCP, using a high-flow nasal cannula (HFNC), in elderly patients. As a multicenter prospective randomized trial, patients who underwent ERCP with propofol-based sedation were randomly assigned into two groups: Patients in the HFNC group were supplied with oxygen via an HFNC, and those in the standard nasal cannula group were supplied with oxygen via a low-flow nasal cannula. The co-primary end points were the lowest oxygen saturation rate and hypoxia during the overall procedure. A total of 187 patients (HFNC group: 95; standard nasal cannula group: 92) were included in the analysis. Unexpected hypoxia events were more frequently observed among patients in the standard nasal cannula group than among patients in the HFNC group (13% vs. 4%, odds ratio 3.41, 95% confidence interval 1.06–11.00, p = 0.031). The mean of the lowest oxygen saturation rate during ERCP was significantly lower in the standard nasal cannula group than in the HFNC group (95% vs. 97%, p = 0.002). Oxygen supplementation with an HFNC can prevent oxygen desaturation and hypoxia events in patients undergoing ERCP under sedation. Trial registration Clinical Research Information Service (CRIS; KCT0004960).
- Subjects :
- Physiology
Sedation
medicine.disease_cause
law.invention
Randomized controlled trial
law
medicine
Cannula
Humans
Prospective Studies
Hypoxia
Adverse effect
Aged
Oxygen saturation (medicine)
Cholangiopancreatography, Endoscopic Retrograde
Endoscopic retrograde cholangiopancreatography
medicine.diagnostic_test
business.industry
Oxygen Inhalation Therapy
Gastroenterology
Oxygenation
Hypoxia (medical)
Oxygen
surgical procedures, operative
Anesthesia
medicine.symptom
business
Nasal cannula
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....5213b6e79a38cdbc5f07af2b4bc17f28
- Full Text :
- https://doi.org/10.1007/s10620-021-07272-z