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An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
- Source :
- Science. 337:1678-1684
- Publication Year :
- 2012
- Publisher :
- American Association for the Advancement of Science (AAAS), 2012.
-
Abstract
- Keeping Cancer Cells At Bay Cancer cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes to the tumorigenic phenotype is not clear. Senovilla et al. (p. 1678 ; see the Perspective by Zanetti and Mahadevan ) found that tetraploidization of cancer cells can cause them to become immunogenic and thus aid in their clearance from the body by the immune system. Cells with excess chromosomes put stress on the endoplasmic reticulum, which leads to movement of the protein calreticulin to the cell surface. Calreticulin exposure in turn caused recognition of cancer cells in mice by the host immune system. Thus, the immune system appears to serve a protective role in eliminating hyperploid cells that must be overcome to allow unrestricted growth of cancer cells.
- Subjects :
- Settore BIO/06
Eukaryotic Initiation Factor-2
medicine.disease_cause
Cell Line
Mice
03 medical and health sciences
0302 clinical medicine
Cell Line, Tumor
Neoplasms
medicine
Animals
Humans
Epigenetics
Phosphorylation
Endoplasmic Reticulum Stre
Immunologic Surveillance
Inbred BALB C
030304 developmental biology
Mice, Inbred BALB C
0303 health sciences
Tumor
Ploidies
Multidisciplinary
biology
Animal
Endoplasmic reticulum
Cancer
DNA, Neoplasm
DNA
Endoplasmic Reticulum Stress
medicine.disease
3. Good health
Immunosurveillance
Common Variable Immunodeficiency
Cell culture
030220 oncology & carcinogenesis
Cancer cell
Immunology
biology.protein
Cancer research
Neoplasm
Calreticulin
Carcinogenesis
Immunocompetence
Human
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 337
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....52143575746bdb7bd641e3741b46924c