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Hyperglycemia-Induced Hypovolemia Is Involved in Early Cardiac Magnetic Resonance Alterations in Streptozotocin-Induced Diabetic Mice: A Comparison with Furosemide-Induced Hypovolemia
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 2, p e0149808 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- AIMS:The aim of the study was to assess the early features of diabetic cardiomyopathy using cardiac magnetic resonance within the first week after streptozotocin injection in mice. We focused on the relationship between left ventricular function and hypovolemia markers in diabetic animals compared to a hypovolemic rodent model. METHODS AND RESULTS:Swiss mice were randomized into control (group C), streptozotocin-induced diabetes (group D) and furosemide-induced hypovolemia (group F) groups. Cardiac magnetic resonance, non-invasive blood pressure, urine volume, plasma markers of dehydration and cardiac histology were assessed in all groups. Mean blood glucose was higher in diabetic animals than in groups C and F (30.5±5.8 compared to 10.4±2.1 and 11.1±2.8 mmol/L, respectively; p
- Subjects :
- Male
Physiology
Hypovolemia
lcsh:Medicine
030204 cardiovascular system & hematology
Mice
0302 clinical medicine
Endocrinology
Fibrosis
Furosemide
Diabetic cardiomyopathy
Medicine and Health Sciences
Magnetic Resonance
lcsh:Science
Mammals
Multidisciplinary
medicine.diagnostic_test
Physics
Magnetism
Hematology
Condensed Matter Physics
Magnetic Resonance Imaging
Blood Sugar
Body Fluids
Blood
Physiological Parameters
Vertebrates
Physical Sciences
medicine.symptom
Anatomy
Cardiomyopathies
medicine.drug
Research Article
medicine.medical_specialty
Endocrine Disorders
Cardiology
Blood sugar
030209 endocrinology & metabolism
Rodents
Blood Plasma
Diabetes Mellitus, Experimental
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Animals
business.industry
lcsh:R
Body Weight
Organisms
Biology and Life Sciences
Magnetic resonance imaging
medicine.disease
Streptozotocin
Cardiac Imaging Techniques
Metabolic Disorders
Hyperglycemia
lcsh:Q
business
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....52174a2f60cb68fb88ed29e7590e10f4