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Age Modulates the Association of Caffeine Intake With Cognition and With Gray Matter in Elderly Diabetics
- Source :
- The Journals of Gerontology: Series A. 74:683-688
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- BACKGROUND: The association between caffeine and cognitive performance has not been tested in older individuals with type 2 diabetes (T2D). Its association with brain volume in T2D has been tested only in animals. METHODS: We examined the association of caffeine with cognitive function and brain volume in a sample of elderly diabetics participating in the Israel Diabetes and Cognitive Decline Study (n = 638) and the moderating effect of age on this association. In a subsample (n = 185) with magnetic resonance imaging, we also examined these associations with gray and white matter volumes (GM/WM). RESULTS: Using linear regression adjusting for cognition-related covariates, we found that higher caffeine intake was associated with better function in overall cognition (p = .018), attention/working memory (p = .002), executive functioning (p = .047), and semantic categorization (p = .026). Interaction analyses of caffeine intake with age were significant for semantic categorization (p = .025), and approached significance for overall cognition (p = .066). This association was driven by the older group (above-median) for whom the association of caffeine intake with semantic categorization (p = .001), attention/working memory (p = .007), executive functioning (p = .005), and overall cognition (p = .002) were significant. In the magnetic resonance imaging subsample, there was an interaction (p = .034) of caffeine intake with age for GM volume; in the older group, higher caffeine intake was associated with greater GM volume (β = .198, p = .033). CONCLUSIONS: Caffeine intake may have a beneficial role in cognitive functioning of elderly adults with T2D, which may be moderated by age. Greater GM volume may be a mechanism underlying the association of higher caffeine intake with better cognitive function.
- Subjects :
- Male
Aging
Physiology
Type 2 diabetes
03 medical and health sciences
chemistry.chemical_compound
Cognition
0302 clinical medicine
Caffeine
Diabetes mellitus
Humans
Medicine
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
Gray Matter
Israel
Cognitive decline
Aged
business.industry
Working memory
Organ Size
medicine.disease
Magnetic Resonance Imaging
White Matter
Diabetes Mellitus, Type 2
chemistry
The Journal of Gerontology: Medical Sciences
Brain size
Female
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1758535X and 10795006
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology: Series A
- Accession number :
- edsair.doi.dedup.....524811a0d7ae34e9b469f0ef6e8ea291