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Invasive infections due to Saprochaete and Geotrichum species: report of 23 cases from the FungiScope Registry
- Source :
- Mycoses. John Wiley and Sons Ltd
- Publication Year :
- 2017
-
Abstract
- Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope™ registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co-morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S. capitata (n=14), S. clavata (n=5), G. candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S. capitata and S. clavata isolates with the exception of one S. capitata (MIC 4 mg/L) isolate had MICs>32 mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32 mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B ± flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.
- Subjects :
- 0301 basic medicine
Male
Pathology
Saprochaete
Antifungal Agents
invasive fungal diseases
Gastroenterology
Flucytosine
chemistry.chemical_compound
Echinocandins
Amphotericin B
Registries
Fluconazole
General Medicine
Middle Aged
Geotrichum
3. Good health
Infectious Diseases
Female
Fungemia
medicine.drug
Adolescent
Adult
Aged
Geotrichosis
Humans
Immunocompromised Host
Invasive Fungal Infections
Lipopeptides
Microbial Sensitivity Tests
Neutropenia
Saccharomycetales
Voriconazole
Young Adult
2708
medicine.medical_specialty
Echinocandin
030106 microbiology
Dermatology
Biology
03 medical and health sciences
Internal medicine
medicine
Micafungin
Settore MED/15 - MALATTIE DEL SANGUE
chemistry
Anidulafungin
Caspofungin
Subjects
Details
- Language :
- English
- ISSN :
- 09337407
- Database :
- OpenAIRE
- Journal :
- Mycoses
- Accession number :
- edsair.doi.dedup.....524aaafdd28187a2a01180f94af06075