Phenotypic Screens in Antimalarial Drug Discovery

Phenotypic high throughput screens are a valuable tool for identifying new chemical compounds with antimalarial activity. Traditionally, these screens have focused solely on the symptomatic asexual blood stage of the parasite's lifecycle; however, in order to discover new medicines for malaria's treatment and prevention, robust screening technologies against other parasite lifecycle stages are required. This review highlights recent advances and progress toward phenotypic screening methodologies over the past several years, with a focus on exoerythrocytic stage screens.