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Regulation of neutrophil apoptosis by Mcl-1
- Source :
- Biochemical Society Transactions. 32:489-492
- Publication Year :
- 2004
- Publisher :
- Portland Press Ltd., 2004.
-
Abstract
- Neutrophils rapidly undergo spontaneous apoptosis, but this process can be considerably delayed by exposure to a variety of agents such as pro-inflammatory cytokines. The anti-apoptotic protein of the Bcl-2 family, Mcl-1, plays a key role in the regulation of neutrophil apoptosis. The protein has some unusual properties compared with other family members, including an extremely high turnover rate. Many factors, such as cytokines and local oxygen concentrations, can regulate cellular levels of Mcl-1 via transcription and post-transcriptional modification, control the survival time of neutrophils within tissues and thereby influence the inflammatory response.
- Subjects :
- Cell Survival
Neutrophils
Inflammatory response
Neutrophil apoptosis
Apoptosis
Inflammation
Biology
Biochemistry
Transcription (biology)
medicine
Animals
Humans
RNA, Messenger
Cloning, Molecular
RNA Processing, Post-Transcriptional
High turnover
RNA
Oxidants
Neoplasm Proteins
Cell biology
Oxygen
Myeloid Cell Leukemia Sequence 1 Protein
Proto-Oncogene Proteins c-bcl-2
Immunology
Cytokines
medicine.symptom
Subjects
Details
- ISSN :
- 14708752 and 03005127
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Biochemical Society Transactions
- Accession number :
- edsair.doi.dedup.....525053890f73057fd691eb90ef64089e