Back to Search
Start Over
Cytotoxic Spliceostatin Analogs from Pseudomonas sp
- Source :
- Chemistrybiodiversity. 16(9)
- Publication Year :
- 2019
-
Abstract
- Two new spliceostatin analogs, designed as spliceostatins J and K (1 and 2), were isolated and identified from the culture of Pseudomonas sp., along with two known ones, FR901464 (3) and spliceostatin E (4). Their structures were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS. Spliceostatin J (1) represented the first example of spliceostatins bearing an unusual hexahydrofuro[3,4-b]furan moiety. Biological assay showed all the isolated compounds except 1 displayed potent cytotoxic activities against two cancer cell lines (MDA-MB-231 and A-549). Structure-activity-relationship studies revealed that the tetrahydropyran ring in spliceostatin analogs was necessary for their bioactive retention.
- Subjects :
- Stereochemistry
Bioengineering
Antineoplastic Agents
01 natural sciences
Biochemistry
chemistry.chemical_compound
Lactones
Structure-Activity Relationship
Furan
Cell Line, Tumor
Pseudomonas
Moiety
Cytotoxic T cell
Humans
Spiro Compounds
Cytotoxicity
Furans
Molecular Biology
Cell Proliferation
Pyrans
biology
Dose-Response Relationship, Drug
Molecular Structure
010405 organic chemistry
Biological activity
General Chemistry
General Medicine
Tetrahydropyran
biology.organism_classification
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
A549 Cells
Pyrones
Molecular Medicine
Drug Screening Assays, Antitumor
Bacteria
Subjects
Details
- ISSN :
- 16121880
- Volume :
- 16
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Chemistrybiodiversity
- Accession number :
- edsair.doi.dedup.....526cbd536d77f4b2abc9c11cc4d378e3