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Alterations of NURR1 and Cytokines in the Peripheral Blood Mononuclear Cells: Combined Biomarkers for Parkinson’s Disease
- Source :
- Frontiers in Aging Neuroscience, Vol 10 (2018), Frontiers in Aging Neuroscience
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- Nuclear receptor related 1 protein (NURR1), a transcription factor as key player for maintaining dopamine neuron functions and regulating neuroinflammation in the central nerves system, is a potential susceptibility gene for Parkinson’s disease (PD). To ascertain whether the expression levels of NURR1 gene and inflammatory cytokines are altered in patients with PD, we measured their mRNA levels in the peripheral blood mononuclear cells (PBMCs) in 312 PD patients, 318 healthy controls (HC), and 332 non-PD neurological disease controls (NDCs) by quantitative real-time PCR. Our data showed that NURR1 gene expression was significantly decreased in the PBMCs of PD as compared with that of HC and NDC (p < 0.01). Since NURR1 was reported to have regulating effects on neuroinflammation, we assessed the expression levels of cytokines (TNF-α, IL-1β, IL-4, IL-6, and IL-10) in the PBMCs of PD and controls (HC and NDC). Our results showed that the expression levels of those cytokines were significantly higher than those of controls. Statistical analysis revealed that NURR1 expression presented a negative correlation with the expression of TNF-α, IL-1β, IL-6, and IL-10, and collectively the measurements of NURR1 plus those cytokines significantly improve the diagnostic accuracy. All these findings suggested that NURR1 is likely to be involved in the process of PD by mediating the neuroinflammation, and the combination of NURR1 and cytokines assessment in the PBMCs can be potential biomarkers for PD diagnosis.
- Subjects :
- 0301 basic medicine
NURR1
Aging
Parkinson's disease
Cognitive Neuroscience
medicine.medical_treatment
Nuclear receptor related-1 protein
Peripheral blood mononuclear cell
Proinflammatory cytokine
neuroinflammation
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
Gene expression
medicine
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Neuroinflammation
Original Research
biology
business.industry
biomarkers
medicine.disease
cytokines
030104 developmental biology
Cytokine
Immunology
biology.protein
Parkinson’s disease
Biomarker (medicine)
business
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....526cc2207dae91a7789a705f3f8584d0