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Air pollution interacts with genetic risk to influence cortical networks implicated in depression
- Source :
- Proc Natl Acad Sci U S A
- Publication Year :
- 2021
- Publisher :
- National Academy of Sciences, 2021.
-
Abstract
- Air pollution is a reversible cause of significant global mortality and morbidity. Epidemiological evidence suggests associations between air pollution exposure and impaired cognition and increased risk for major depressive disorders. However, the neural bases of these associations have been unclear. Here, in healthy human subjects exposed to relatively high air pollution and controlling for socioeconomic, genomic, and other confounders, we examine across multiple levels of brain network function the extent to which particulate matter (PM(2.5)) exposure influences putative genetic risk mechanisms associated with depression. Increased ambient PM(2.5) exposure was associated with poorer reasoning and problem solving and higher-trait anxiety/depression. Working memory and stress-related information transfer (effective connectivity) across cortical and subcortical brain networks were influenced by PM(2.5) exposure to differing extents depending on the polygenic risk for depression in gene-by-environment interactions. Effective connectivity patterns from individuals with higher polygenic risk for depression and higher exposures with PM(2.5), but not from those with lower genetic risk or lower exposures, correlated spatially with the coexpression of depression-associated genes across corresponding brain regions in the Allen Brain Atlas. These converging data suggest that PM(2.5) exposure affects brain network functions implicated in the genetic mechanisms of depression.
- Subjects :
- Adult
Biology
Anxiety
complex mixtures
Risk Factors
Environmental health
Air Pollution
medicine
Humans
Gene–environment interaction
Depression (differential diagnoses)
Air Pollutants
Multidisciplinary
Working memory
Depression
Brain atlas
Confounding
Brain
Cognition
Environmental Exposure
Biological Sciences
medicine.disease
Major depressive disorder
Particulate Matter
medicine.symptom
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Proc Natl Acad Sci U S A
- Accession number :
- edsair.doi.dedup.....5282e8fbdd535c314b0ea44ac2f09d3a