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Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial
- Source :
- Jensen, S K, Jensen, T M, Birk, N M, Stensballe, L G, Benn, C S, Jensen, K J, Pryds, O, Jeppesen, D L & Nissen, T N 2020, ' Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial ', Vaccine, vol. 38, no. 11, pp. 2449-2455 . https://doi.org/10.1016/j.vaccine.2020.02.006
- Publication Year :
- 2020
-
Abstract
- Background The Bacille Calmette-Guerin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants. Method The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (109 cells/L)) measured in peripheral blood. Results Overall, we found no effect of BCG on differential WBC counts at any time point. Conclusion BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.
- Subjects :
- Trained innate immunity
Tuberculosis
Denmark
030231 tropical medicine
White blood cell differential count
Basophil
Bacille Calmette Guerin
Non-specific effects
Cohort Studies
03 medical and health sciences
Leukocyte Count
0302 clinical medicine
Heterologous immunity
White blood cell
Bacillus Calmette-Guérin
medicine
Humans
030212 general & internal medicine
General Veterinary
General Immunology and Microbiology
business.industry
Vaccination
Public Health, Environmental and Occupational Health
Infant, Newborn
Infant
Eosinophil
medicine.disease
Clinical trial
Infectious Diseases
medicine.anatomical_structure
Immunology
Cohort
BCG Vaccine
Molecular Medicine
business
Infants
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Jensen, S K, Jensen, T M, Birk, N M, Stensballe, L G, Benn, C S, Jensen, K J, Pryds, O, Jeppesen, D L & Nissen, T N 2020, ' Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial ', Vaccine, vol. 38, no. 11, pp. 2449-2455 . https://doi.org/10.1016/j.vaccine.2020.02.006
- Accession number :
- edsair.doi.dedup.....52a8fe4f7b3d3f3c3446ec162a4ec149