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Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers
- Source :
- Frontiers in Oncology, Frontiers in Oncology, Vol 8 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media SA, 2018.
-
Abstract
- Combined loss of tumor suppressors (TSPs) PTEN, TP53, and RB1 is highly associated with small cell carcinoma of prostate phenotype. Recent genomic studies of human tumors as well as analyses in mouse genetic models have revealed a unique role for these TSPs in dictating epithelial lineage plasticity – a phenomenon that plays a critical role in the development of aggressive variant prostate cancer and associated androgen therapy resistance. Here, we summarize recently published key observations on this topic, and hypothesize a possible mechanism by which concurrent loss of TSPs could potentially regulate the prostate cancer disease phenotype.
- Subjects :
- 0301 basic medicine
Cancer Research
therapy resistance
Mini Review
lineage plasticity
lcsh:RC254-282
Small-cell carcinoma
03 medical and health sciences
Prostate cancer
Prostate
Genetic model
medicine
PTEN
Epithelial–mesenchymal transition
tumor suppressors
neuroendocrine prostate cancer
biology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Phenotype
3. Good health
030104 developmental biology
medicine.anatomical_structure
Oncology
Androgen Therapy
biology.protein
Cancer research
epithelial-to-mesenchymal transition
Subjects
Details
- ISSN :
- 2234943X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in Oncology
- Accession number :
- edsair.doi.dedup.....52ca00f6f510ac46a9863df90522fa35