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Chemotherapy-induced amenorrhea in patients with breast cancer with a BRCA1 or BRCA2 mutation
- Source :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 31(31)
- Publication Year :
- 2013
-
Abstract
- PURPOSE: To determine the likelihood of long-term amenorrhea after treatment with chemotherapy in women with breast cancer who carry a BRCA1 or BRCA2 mutation. PATIENTS AND METHODS: We conducted a multicenter survey of 1,954 young women with a BRCA1 or BRCA2 mutation who were treated for breast cancer. We included premenopausal women who were diagnosed with invasive breast cancer between 26 and 47 years of age. We determined the age of onset of amenorrhea after breast cancer for women who were and were not treated with chemotherapy, alone or with tamoxifen. We considered chemotherapy-induced amenorrhea to have occurred when the patient experienced ≥ 2 years of amenorrhea, commencing within 2 years of initiating chemotherapy, with no resumption of menses. RESULTS: Of the 1,426 women who received chemotherapy, 35% experienced long-term amenorrhea. Of the 528 women who did not receive chemotherapy, 5.3% developed long-term amenorrhea. The probabilities of chemotherapy-induced amenorrhea were 7.2% for women diagnosed before age 30 years, 33% for women age 31 to 44 years, and 79% for women diagnosed after age 45 years (P trend < .001). The probability of induced amenorrhea was higher for women who received tamoxifen than for those who did not (52% v 29%; P < .001). CONCLUSION: Age at treatment and use of tamoxifen are important predictors of chemotherapy-induced amenorrhea in women who carry a BRCA1 or BRCA2 mutation. The risk of induced long-term amenorrhea does not seem to be greater among mutation carriers than among women who do not carry a mutation.<br />published_or_final_version
- Subjects :
- Adult
endocrine system
Cancer Research
medicine.medical_specialty
endocrine system diseases
medicine.medical_treatment
Genes, BRCA2
Genes, BRCA1
Breast Neoplasms
Chemotherapy induced amenorrhea
BRCA2 Mutation
Breast cancer
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
In patient
skin and connective tissue diseases
Amenorrhea
Gynecology
Chemotherapy
business.industry
Obstetrics
Data Collection
Age Factors
ORIGINAL REPORTS
Middle Aged
medicine.disease
Tamoxifen
Oncology
Mutation
Female
medicine.symptom
Age of onset
business
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 15277755
- Volume :
- 31
- Issue :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....52dfef5905f0c3c43eda830bffa916fe