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Investigations of cellular immunity in juvenile idiopathic arthritis

Authors :
Genel Sur
Lucia Sur
Iulia Lupan
Gabriel Samasca
Source :
Central European Journal of Immunology, Vol 44, Iss 1, Pp 92-96 (2019), Central-European Journal of Immunology
Publication Year :
2019
Publisher :
Termedia Publishing House, 2019.

Abstract

The following was emphasised in an informative, educational issued on the American College of Rheumatology website in April 2017: "About one child in every 1000 develops some type of chronic arthritis. These disorders can affect children at any age, although rarely in the first six months of life. It is estimated that around 300,000 children in the United States have been diagnosed with the condition". Therefore, knowledge of immunological investigations in patients with juvenile idiopathic arthritis is important for finding new treatment pathways. Our aim was to assess the immunological investigations and immune system implications in juvenile idiopathic arthritis. We will discuss: a) the specifically targeted proteins - the citrullinated peptide antibodies; b) non-specifically targeted proteins - heat-shock proteins (anti-HSP60, -65, and -70 antibodies), CLEC16A, inflammasomes, and phagocyte-derived S100; c) interleukins - IL-1, IL-6, IL-10, IL-17, and IL-18; d) innate immunity - macrophage activation syndrome, natural killer cells, complement activity, and immune complexes; and e) therapeutic targets - monoclonal antibodies, JAK inhibitors, and intravenous immune globulin.

Details

Language :
English
ISSN :
16444124 and 14263912
Volume :
44
Issue :
1
Database :
OpenAIRE
Journal :
Central European Journal of Immunology
Accession number :
edsair.doi.dedup.....52f4a14abe02d921177bf9cf878d8489