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Objective and subjective measures of dalfampridine efficacy in clinical practice
- Source :
- Multiple Sclerosis Journal-Experimental, Translational and Clinical
- Publication Year :
- 2018
- Publisher :
- SAGE Publications, 2018.
-
Abstract
- Background Multiple sclerosis affects mobility in over 80% of patients. Dalfampridine is the only approved treatment for walking impairment in multiple sclerosis. We assessed dalfampridine utilization in our practice and investigated response using timed 25 foot walk (T25FW) improvement and a patient-reported ambulation inventory. Methods Chart review identified patients with multiple sclerosis for whom dalfampridine was prescribed. T25FW data were extracted from medical records. Participants completed a dalfampridine-specific version of the multiple sclerosis walking scale (dMSWS-12) to assess the qualitative impact of dalfampridine on ambulation. We evaluated two responder categories: liberally defined as any improvement in T25FW; and over 20% T25FW improvement. Results The dMSWS-12 questionnaire was completed by 39 patients. Eighteen patients (46%) did not show any T25FW improvement. Of the 21 patients (54%) with T25FW improvement, four patients (11%) showed improvement greater than 20%. Analysis of dMSWS-12 scores showed a median score of 40 (range 12–60). Eleven patients (28%) showed no improvement (dMSWS-12 score ≤36). In contrast to objective T25FW improvement (54%), 28 patients (72%) reported improvement in walking ability (dMSWS-12 score ≥37). Conclusion Our results suggest that T25FW alone might not be sufficient for response characterization and that adding patient-reported measures may further elucidate the therapeutic response.
- Subjects :
- Median score
medicine.medical_specialty
timed 25 foot walk
business.industry
Multiple sclerosis
Medical record
treatment response
medicine.disease
gait
Gait
Timed 25 foot walk
Clinical Practice
Original Research Paper
Cellular and Molecular Neuroscience
Chart review
dalfampridine
Physical therapy
Medicine
Neurology (clinical)
business
outcome measurement
Walking scale
Subjects
Details
- Language :
- English
- ISSN :
- 20552173
- Volume :
- 4
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis Journal - Experimental, Translational and Clinical
- Accession number :
- edsair.doi.dedup.....52f8b50424442cce7e9aeafab12a5eac