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Rational design of potent GSK3β inhibitors with selectivity for Cdk1 and Cdk2
- Source :
- Bioorganic & Medicinal Chemistry Letters. 20:1985-1989
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- From an HTS hit, a series of potent and selective inhibitors of GSK3β have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.
- Subjects :
- Models, Molecular
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Substrate Specificity
Glycogen Synthase Kinase 3
GSK-3
CDC2 Protein Kinase
Drug Discovery
Transferase
Protein Kinase Inhibitors
Molecular Biology
Cyclin-dependent kinase 1
Glycogen Synthase Kinase 3 beta
biology
Chemistry
Cyclin-Dependent Kinase 2
Organic Chemistry
Cyclin-dependent kinase 2
Rational design
Drug Design
biology.protein
Molecular Medicine
biological phenomena, cell phenomena, and immunity
Selectivity
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....52fd7bd1858589017041fe68fdcfe9e7
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.01.114