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Lack of Prognostic Value of Human Epidermal Growth Factor- Like Receptor 2 Status in Inflammatory Breast Cancer (IBC): a Meta-analysis
- Source :
- Asian Pacific Journal of Cancer Prevention. 15:9615-9619
- Publication Year :
- 2014
- Publisher :
- Asian Pacific Organization for Cancer Prevention, 2014.
-
Abstract
- Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer which is more likely to be her-2/ neu amplified. While the her-2/neu status has been utilised to predict prognosis, the published data are inconsistent. The present meta-analysis was conducted to determine whether the her-2/neu status predicts outcomes. Papers were selected from the PubMed database based on defined inclusion and exclusion criteria. Parameters such as total patients, follow-up time and outcome statistics (i.e. overall survival (OS), relapse-free survival (RFS) were collected. The analysis included 6 studies with 2,838 IBC patients. The summary hazards ratio (HR) estimating the association of OS with HER-2-positive disease was 0.96 (95% confidence interval (95%CI: 0.85-1.10)), with similar findings for RFS (HR=0.81, 95%CI: 0.61-1.09). No obvious statistical heterogeneity was detected. This meta-analysis suggests that HER-2-positive status is not an independent adverse prognostic factor for survival among IBC patient cases.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Receptor, ErbB-2
Epidemiology
Antineoplastic Agents
Breast Neoplasms
Antibodies, Monoclonal, Humanized
Inflammatory breast cancer
Disease-Free Survival
Breast cancer
Trastuzumab
Internal medicine
Humans
Medicine
skin and connective tissue diseases
Survival rate
business.industry
Hazard ratio
Public Health, Environmental and Occupational Health
medicine.disease
Confidence interval
Survival Rate
Study heterogeneity
Treatment Outcome
Meta-analysis
Female
Neoplasm Recurrence, Local
business
medicine.drug
Subjects
Details
- ISSN :
- 15137368
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....53274c6d1774822672388a90c048fc78