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Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenetic and prognostic implications
- Publication Year :
- 2010
-
Abstract
- Additional chromosome abnormalities (ACAs) occur in less than 10% of cases at diagnosis of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). In some cases, on the basis of the persistence of the ACAs in Ph-negative cells after response to imatinib, a secondary origin of the Ph chromosome has been demonstrated. In this study, the possible prognostic value of this phenomenon was evaluated. Thirty-six Ph-positive CML patients were included in the study. In six patients, ACAs persisted after the disappearance of the Ph. A complete cytogenetic response (CCR) was obtained in five of these six patients, and five of six also had a high Sokal score. In all the other cases, ACAs disappeared together (in cases of response to therapy with imatinib) or persisted with the Ph (in cases of no response to imatinib). In the former cases, the primary origin of the Ph was demonstrated. CCR was obtained in 22 cases (17 with low to intermediate Sokal scores), while no response was observed in 8 patients (5 with a high Sokal score). Sokal score seems to maintain its prognostic value for patients in whom the Ph occurs as a primary event, but not in those in whom it occurs as a secondary one.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Antineoplastic Agents
Biology
Philadelphia chromosome
Gastroenterology
Piperazines
NO
Myelogenous
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
hemic and lymphatic diseases
Internal medicine
Aged
Aged, 80 and over
Benzamides
Female
Humans
Imatinib Mesylate
Karyotyping
Middle Aged
Protein-Tyrosine Kinases
Pyrimidines
Remission Induction
Treatment Outcome
Chromosome Aberrations
Philadelphia Chromosome
Molecular Biology
Genetics
80 and over
medicine
Chronic
Leukemia
Karyotype
Imatinib
medicine.disease
Imatinib mesylate
Immunology
BCR-ABL Positive
Sokal Score
Chronic myelogenous leukemia
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....532b58a4912c9e64d64394c36699fbbf