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Clinical Significance of Cyclophilin A Expression in Esophageal Squamous Cell Carcinoma
- Source :
- Genetic Testing and Molecular Biomarkers. 19:182-186
- Publication Year :
- 2015
- Publisher :
- Mary Ann Liebert Inc, 2015.
-
Abstract
- Objective: To explore the expression of cyclophilin A (CypA) in esophageal tissues and its clinical significance. Method: Expression of CypA was detected in 236 esophageal cancer tissues and 236 normal tissues by using an immunohistochemical method, and the relationship between CypA expression and clinical outcomes was observed. Results: There were 166 patients with high expression of CypA (70.23%) and a higher expression in 69.3% of males and 73.3% in females. The CypA expression was irrelevant to age, tumor location, lymph node metastasis, and tumor differentiation degree. The Kaplan–Meier survival curve analysis showed that the expression of CypA was associated with the prognosis of patients with esophageal squamous cell carcinoma. Conclusion: The poor prognosis of esophageal cancer patients was associated with high expression of CypA.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Esophageal Neoplasms
Cypa
Gene Expression Regulation, Enzymologic
Internal medicine
medicine
Carcinoma
Humans
Clinical significance
Survival rate
Genetics (clinical)
Survival analysis
Aged
Regulation of gene expression
biology
business.industry
General Medicine
Middle Aged
Esophageal cancer
biology.organism_classification
medicine.disease
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
Survival Rate
Carcinoma, Squamous Cell
Immunohistochemistry
Female
business
Cyclophilin A
Subjects
Details
- ISSN :
- 19450257 and 19450265
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Genetic Testing and Molecular Biomarkers
- Accession number :
- edsair.doi.dedup.....532d3481ba31ed6e7db09f9a37400ec5