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Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants
- Publication Year :
- 2022
-
Abstract
- Background Caffeine is widely used in preterm infants for apnea control. It has no effect on sleep in the only existing polysomnographic study including ten preterm infants Behavioral and polygraphic studies have conflicting results. Methods We studied 21 late-preterm infants at a median gestational age of 36 weeks. Polysomnography was performed twice, at baseline on day 1 and on the day after the onset of caffeine treatment (20 mg/kg loading and 5 mg/kg morning maintenance dose). Results Caffeine acted short term as a breathing stimulant with reduction of apneas, improved baseline SpO2 (p p 2 desaturations of more than 5% (p p = 0.88). Conclusions In late-preterm infants, caffeine has a clear short-term respiratory stimulant effect, and it increases the arousal frequency to hypoxia. However, caffeine does not appear to act as a central nervous system stimulant, and it has no acute effect on sleep quality. Impact Effects of caffeine on sleep in preterm infants has previously been investigated with only one full polysomnographic study including ten preterm infants. The study showed no effect. The current study shows that caffeine acts short term as a respiratory stimulant and increases arousal frequency to hypoxia. Although a potent central nervous system (CNS) stimulant in adults, caffeine does not seem to have similar acute CNS effect in late-preterm infants. The onset of caffeine treatment has no short-term effect on sleep stage distribution, sleep efficiency, frequency of sleep stage transitions, appearance of REM periods, or the high number of spontaneous arousals.
- Subjects :
- BRAIN-DEVELOPMENT
medicine.medical_treatment
Respiratory System Agents
PREMATURE
Polysomnography
ORGANIZATION
THERAPY
Arousal
chemistry.chemical_compound
3123 Gynaecology and paediatrics
Caffeine
APNEA
Humans
Medicine
Hypoxia
medicine.diagnostic_test
business.industry
Maintenance dose
Infant, Newborn
Infant
Gestational age
Apnea
Carbon Dioxide
AROUSAL
STATE
Stimulant
chemistry
Anesthesia
Pediatrics, Perinatology and Child Health
Breathing
Central Nervous System Stimulants
medicine.symptom
Sleep
business
Infant, Premature
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....536464f3db9f6eb8dda66fdbab7bf063