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Identification of a regulatory Vδ1 gamma delta T cell subpopulation expressing CD73 in human breast cancer
- Source :
- Journal of Leukocyte Biology, Journal of Leukocyte Biology, Society for Leukocyte Biology, In press, ⟨10.1002/JLB.3MA0420-278RR⟩
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- γδ T cells contribute to the immune response against many cancers, notably through their powerful effector functions that lead to the elimination of tumor cells and the recruitment of other immune cells. However, their presence in the tumor microenvironment has been associated with poor prognosis in breast, colon, and pancreatic cancer, suggesting that γδ T cells may also display pro-tumor activities. Here, we identified in blood from healthy donors a subpopulation of Vδ1T cells that represents around 20% of the whole Vδ1 population, expresses CD73, and displays immunosuppressive phenotype and functions (i.e., production of immunosuppressive molecules, such as IL-10, adenosine, and the chemotactic factor IL-8, and inhibition of αβ T cell proliferation). We then found that in human breast tumors, γδ T cells were present particularly in late stage breast cancer samples, and that ∼20% of tumor-infiltrating γδ T cells expressed CD73. Taken together, these results suggest that regulatory γδ T cells are present in the breast cancer microenvironment and may display immunosuppressive functions through the production of immunosuppressive molecules, such as IL-10, IL-8, and adenosine, thus promoting tumor growth.
- Subjects :
- Adenosine
Receptors, Antigen, T-Cell, alpha-beta
medicine.medical_treatment
Lymphocyte Activation
T-Lymphocytes, Regulatory
0302 clinical medicine
Tumor Microenvironment
Immunology and Allergy
Gamma delta T cell
5'-Nucleotidase
0303 health sciences
education.field_of_study
Cell Differentiation
Receptors, Antigen, T-Cell, gamma-delta
Immunosuppression
Middle Aged
Interleukin-10
3. Good health
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
[SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy
Signal Transduction
Adult
Adolescent
[SDV.IMM] Life Sciences [q-bio]/Immunology
Primary Cell Culture
Immunology
Population
Breast Neoplasms
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
GPI-Linked Proteins
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
Immune system
Breast cancer
[SDV.CAN] Life Sciences [q-bio]/Cancer
Pancreatic cancer
medicine
Humans
Cell Lineage
education
Aged
030304 developmental biology
Tumor microenvironment
Interleukin-8
Cancer
[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
Cell Biology
medicine.disease
Case-Control Studies
Cancer research
030215 immunology
Subjects
Details
- ISSN :
- 19383673 and 07415400
- Volume :
- 107
- Database :
- OpenAIRE
- Journal :
- Journal of Leukocyte Biology
- Accession number :
- edsair.doi.dedup.....5382933c520023fa9c5995983d21a1aa