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Microcalorimetry studies of the antimicrobial actions of Aconitum alkaloids
- Source :
- Journal of Zhejiang University. Science. B. 16(8)
- Publication Year :
- 2015
-
Abstract
- The metabolic activity of organisms can be measured by recording the heat output using microcalorimetry. In this paper, the total alkaloids in the traditional Chinese medicine Radix Aconiti Lateralis were extracted and applied to Escherichia coli and Staphylococcus aureus. The effect of alkaloids on bacteria growth was studied by microcalorimetry. The power-time curves were plotted with a thermal activity monitor (TAM) air isothermal microcalorimeter and parameters such as growth rate constant (μ), peak-time (Tm), inhibitory ratio (I), and enhancement ratio (E) were calculated. The relationships between the concentration of Aconitum alkaloids and μ of E. coli or S. aureus were discussed. The results showed that Aconitum alkaloids had little effect on E. coli and had a potentially inhibitory effect on the growth of S. aureus.
- Subjects :
- Isothermal microcalorimetry
Stereochemistry
Bacterial growth
Calorimetry
medicine.disease_cause
Bacterial Physiological Phenomena
Radix Aconiti
General Biochemistry, Genetics and Molecular Biology
Alkaloids
medicine
heterocyclic compounds
General Pharmacology, Toxicology and Pharmaceutics
Escherichia coli
Aconitum
Cell Proliferation
Chromatography
General Veterinary
biology
Dose-Response Relationship, Drug
Plant Extracts
General Medicine
Articles
biology.organism_classification
Antimicrobial
Anti-Bacterial Agents
Activity monitor
Staphylococcus aureus
Energy Metabolism
Subjects
Details
- ISSN :
- 18621783
- Volume :
- 16
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Zhejiang University. Science. B
- Accession number :
- edsair.doi.dedup.....53c54f5e010becd2307d2b1321410dba